Solving Challenges of Complex Interventions in
Coronary and Peripheral Arterial Diseases (CAD and PAD)

Risk Factors
Advanced Age
A history of smoking
Family history
Diabetes
Lifestyle
High cholesterol
Excess weight
High blood pressure
Number of Patients
~197 Million Worldwide CAD*
18.2 Million US CAD (age >20 yrs.)+
>202 Million Worldwide PAD#
18-19.5 Million US PAD#
* Roth, G.A., et al., Global Burden of Cardiovascular Disease and Risk Factors, 1990-2019. JACC 2020; 2982-3021. + https://www.cdc.gov/heartdisease/facts.html # Yost, ML, NCVH 2018